Cure for Type 1 Diabetes

Cure for Type 1 Diabetes begins Phase ll Testing

Dr. Denise L. Faustman has announced that a possible cure for type 1 diabetes using an 80 year old very safe TB vaccine will begin trials in July, 2015.

Dr. Faustman working on Cure for Type 1 diabetes
Dr. Faustman working on Cure for Type 1 diabetes

Since 2001, Dr. Faustman has been working on this possible use for the alternative use of BCG an old and safe TB vaccine as a way to help regenerate pancreas beta cells and end type 1 diabetes.

Progress on the use of the vaccine has been aided and acclerated by research from other countries using results from her studies.

It is unfortunate that in the United States with its profit based pharmaceutical industry that support has not been forth coming.

Dr. Faustman and friends have raised 19 or the 25 million needed to begin the study…donations would be gratefully accepted as more funds are needed to conduct a full trial instead of the FDA approved mid-state trial that will begin in July, 2015.
Lee Iacocca and his foundation has been a strong supporter of this effort because Diabetes affected someone in his family.

I have been watching this study since 2012 and can’t believe how long it has taken to get this far.

For more information on the study, here are some links with more information.

We have a newsletter you can sign up for,
and people can reach out to us to get more information at
Faustman Lab or by emailing at
diabetestrial@partners.org

or go to
https://www.Facebook.com/FaustmanLab

It is so exciting to see the possibility of a cure for type 1 diabetes approaching the final testing phase with human volunteers.

Please support Dr. Faustman’s efforts with sharing on Facebook, Twitter or anywhere you can.
Cararta
Watch the Video Update Here Click and Go

This has been a long time coming!   As I mentioned in another article I wrote several years ago, finding information about this research takes persistence.  I couldn’t even find a mention of it on the American Diabetes Association website.   Digging into a very few news articles I was able to track down the information that is included in the other article.

From what I have read recently, acceleration of the study and testing has been accomplished by dogged work by Dr. Faustman.

It would be a miracle if people with type 1 diabetes could be cured.  Even with all the modern pumps and gadgets available, insulin dosage is still a hit and miss proposition.
Since needs are affected by many things, like the amount of exercise done, calories in foods consumed and the physical condition of  each person, at best blood sugar readings give a close approximation and indicator of what might be needed.

Translate this into managing care for a 4 year old.  You can see the problems that might cease to exist.

Support Dr. Faustman by visiting the facebook website and reading some of the information provided.   It is revealing.

Here is a reference that validates her credentials in case you have a question.

Denise Faustman

From Wikipedia, the free encyclopedia

Denise L. Faustman, (born 1958[1]) is a U.S. physician and medical researcher. An Associate Professor of Medicine at Harvard University and Director of the Immunobiology Laboratory at Massachusetts General Hospital, her work specializes in diabetes mellitus type 1 (formerly called juvenile diabetes) and other autoimmune diseases.[2] She has worked at Massachusetts General Hospital in Boston since 1985.[1]

Hope for the best!   And help.
Donations for funding this trial can be made here:
Donate Now 

Apply to join the trial:
Dr. Faustman said, “Hi, For anyone who has questions regarding potential trial participation, please remember to contact us directly at diabetestrial@partners.org

If we band together and support this effort, just maybe we can all be part of a miracle.

Cararta

 

What is Diabetes and Who Will “Get” It

 Who Gets Diabetes, the How and the Why

Diabetes mellitus is typically a life long (unceasing) health problem where there are elevated quantities of glucose in the hemoglobin (blood). Since being diagnosed with it can be an emotional, fearful and life changing event, the information provided here about what is diabetes and who will get it, might help educate and calm some of the fear.

Causes of diabetes are often incidence, and risk factors.

  • Incidence relates to life style, eating and exercise habits.
  • Risk factors include a possible genetic connection for people with close relatives with the disease and being categorized as obese.

Diabetes is a Digestive Process Disorder -Defined Below

 

The Pancreas and other organs are involved in What is Diabetes and Who Will “Get” It
The Pancreas and other organs are involved in What is Diabetes and Who Will “Get” It

Insulin, circulated in the blood stream,  is an endocrine hormone made by the pancreas to manage blood glucose (sugar) levels. This disease could be brought on by inadequate blood insulin levels, level of resistance to insulin, or either.

To appreciate this disease, it is necessary to initially know the typical procedure by which what you eat is digested and utilized by the digestive system for use as energy.

How normal digestion should work…

A number of things transpire when what you eat is made absorbable:

  • 1. A sugar called glucose enters the circulatory system from the digestive tract.
  • 2. Glucose is converted into a form used by tissue cells to create and provide energy for the nourishment of all body systems.

The pancreas, a glandular organ of the digestive system  produces the hormone insulin. The role of insulin is to move sugar circulating in the blood  into the cells of  muscular tissue, fatty tissue, and the liver, where it is usually put to use as cellular nourishment or in the case of the liver changed and stored for future use.

Individuals with diabetes have elevated blood glucose levels for the reason that their body can not move digested carbohydrates (sugar-glucose) into fatty tissue, the liver, and the muscular tissue cells. In order for sugar (glucose) to become stockpiled in the cells and converted by the cells for use as energy, insulin must transport it inside.

Diabetes appears as a result of the fact that either:

1. The person’s pancreas doesn’t produce sufficient amounts of the hormone insulin.

2. Their bodies cells do not work with insulin in a normal way.

3. Both of these reasons.  These reasons can possibly created by over consumption of food and when the pancreas can not produce enough insulin to handle the over abundance, then high sugar levels interfere and the cells become insulin resistant.

Imagine that each cell is a small energy factory with doors that are kept locked.  Insulin is the “key” that will unlock the door and let sugar enter to be converted into energy.

With an abundance of unused sugar floating around in the blood stream, some of it attaches to the door lock and prevents insulin from inserting its key so the doors become insulin insensitive  (blocked) and no longer work.

There are several types of Diabetes

At this time there are two significant forms of this disease  and the reasons and chances of developing the disease are varied in each type.

Juvenile or type 1 diabetes can develop at every stage of life, but it is frequently detected in youngsters, teenagers, or young adults. With this type of disease, the human body creates limited or zero insulin  and everyday injections of insulin are required. The specific origin of this type has not been completely documented at the present time, but is the subject of much research.

Adult onset diabetes (type 2) represents the major form diagnosed today and frequently develops in the adult years. Previously it was a disease of older adults and seniors.

Unfortunately, because of high obesity rates, teens and young adults and even children as young as 8 years old are now being diagnosed with it.
Another little know fact is that large numbers of people already have type 2 of this disease, but do not recognize it or know they have it.

Pregnancy or gestational is a less prevalent type of the disease caused by sky-high blood glucose levels. This sometimes occurs unexpectedly, at any time, throughout pregnancy in an expectant mother-to-be who has not been previously diagnosed with diabetes.

Diabetes touches the lives of in excess of 20 million Americans. Almost 40 million Americans have elevated blood sugar levels which place them in a pre-diabetic category (Many times this is present before it turns into a disease and, if treated in this stage could possibly prevent development of full blown diabetes).  Charts and more exact facts and figures are available  here:

Centers for Disease Control and Prevention.
Diabetes Report Card 2012. Atlanta, GA: Centers for Disease Control and Prevention, US Department of Health and Human Services; 2012

With the information above, you should have a clearer idea of what type 1, type 2 and gestational diabetes are and hopefully be able to discern if any of the risk factors listed might apply to you.

For more detailed information on the Endocrine system and your digestive processes and how they work visit http://en.wikipedia.org/wiki/Pancreas.

Your caregiver can perform a blood test or an A1c glucose test which is also available at many pharmacies.  So do a little homework and figure out if you might have this dreaded disease.

Evaluation, treatment and implementing the information you gain by becoming knowledgeable about how your body works may help you avoid the complications of untreated diabetes.
Read more about diabetes complication: Symptoms of Type 2 Diabetes

Blood Sugar Control and SALsalate-Will it Help?

type 2 diabetes

While doing some online research about blood sugar control and type 2 diabetes I ran across an article written by Patrick J. Skerrett and posted on the Harvard Health Blog. Mr. Skerrett was describing his participation in a recent study where the final results are now posted by ClinicalTrials.gov.

Needless to say, it got me to thinking. I was diagnosed with type 2 diabetes more than thirty years ago and have basically used a reasonable diet and exercise to control my blood sugar without taking any diabetic based medication.

However, during this time period, I either took plain old aspirin or Naproxen Sodium an aspirin based drug used to control inflammation. They were prescribed by my health care giver to reduce the pain and inflammation for a hip injury I received in a car accident.

The particular drug targeted in the study is SALsalate another aspirin based drug. Since the study seems to show that participants in the study benefited with lower blood sugar levels even though many of them also had an average weight gain of approximately 2 pounds, I began to wonder if my efforts to control my blood sugar levels using just a diet and exercise had been secretly assisted by my use of aspirin and Naproxen Sodium.

I continue to take the Naproxen daily, always making sure to take it with food and even with those precautions, I have had  two lesions removed from my colon.
No one directly advised me to stop taking the Naproxen, didn’t even relate it to the lesions, but since digestive problems are listed as a side effect for this drug….it got me to thinking, so I did some research which I listed below in study information.

The stated purpose of the study was stated as follows:

” Purpose

Growing evidence over recent years supports a potential role for low grade chronic inflammation in the pathogenesis of insulin resistance and type 2 diabetes. In this study we will determine whether salsalate, a member of the commonly used Non-Steroidal Anti-Inflammatory Drug (NSAID) class, is effective in lowering sugars in patients with type 2 diabetes. The study will determine whether salicylates represent a new pharmacological option for diabetes management. The study is conducted in two stages. The primary objective of the first stage is to select a dose of salsalate that is both well-tolerated and demonstrates a trend toward improvement in glycemic control. The primary objective of Stage 2 of the study is to evaluate the effects of salsalate on blood sugar control in diabetes; the tolerability of salsalate use in patients with type 2 diabetes (T2D); and the effects of salsalate on measures of inflammation, the metabolic syndrome, and cardiac risk.”

For your convenience the recently released report is available at Targeting INflammation Using SALsalate in Type 2 Diabetes (TINSAL-T2D)

I plan to call my caregiver and discuss this study and ask if I should be taking salsalate which seems to have fewer or no digestive upsets instead of the one I a now taking.

Since it is now 6:15 a.m. and she isn’t in her office, I’ll have to update later and reveal her recommendation.

Sometimes we get lucky and do things almost right! For my own information, I did a search on WikipediA and found this excerpt from an article:

“Salsalate is used to reduce pain and inflammation caused by conditions such as rheumatoid arthritis, osteoarthritis, and related rheumatic conditions. Salsalate is also recommended by physicians as an anti-inflammatory alternative to naproxen, and ibuprofen for patients that have had minor stomach bleeding or stomach upset. It has also been used as an alternative to narcotic pain medicine for people with spinal disc protrusion.” Read complete article by clicking on the link below.

There is still a side effect on this drug related to the digestive system, so I’m not sure if changing what I’m taking will make a difference, but the positive is that there is documented information that indicates that there is a positive result when taking this drug to control inflammation for people with or without diabetes….suggesting that it helps reduce blood sugar and may even work as a pre-diabetes preventer.

For more information, I’d suggest reading the WikipediA article..many of the references cited there are unavailable to be listed here. Will Taking Salsalate Help control blood sugar Levels in Type 2 Diabetics

When you have diabetes it is always important to continue learning about diabetes.
Self Education should be part of regimen to control your blood sugar right along with your sugar control diet and exercise.
I still believe that You are What You Eat……..

type 2 diabetes

Fresh & Healthy

Fresh and Healthy is a great way to eat.  Especially the fresh part.

Imagine having a box with your meat, fresh produce, recipes that include a picture of what is for dinner included arriving on your doorstep…ready to cook and eat.
Forget the grocery store, shopping and all that time wasting of you life!
Save up to 50% + Free Shipping at HelloFresh! Code NOV50PHF Valid for new customers only. Ends 11/30/15. Eat fresh & healthy – Shop Now

Dr. Dycus  Click Here the article I wanted you to read is on another site!

Heard from a friend that the meals provided by Diet to Go are really healthy and fresh in addition to just plain tasting good.

You might want to give them a look as they are always running a special so that if it is your first time ordering, you get a  different  offer or discount.

Guess if you live alone, it would be very helpful to have portion controlled food available….save a lot on wasted food.  Hambone, my dog might not care for that arrangement, but it is becoming very interesting to me!

Diet-to-Go: The Calorie Lab Review

Great Video Review of A Weeks Worth of Food. The Reviewer ordered a 1200 a day calorie Vegetarian Diet. Vegetarian isn’t required, Diet to Go also has meats and animal protein and  Diary available……no need to go on a diet and become a vegetarian at the same time.

Enjoy!

Cararta

Diabetes Month Get Informed, Fight Diabetes Type 2

type 2 diabetes

Research, some of it has suggested there is a “cure” or reversal for type 2 diabetes.   Wonder if it will happen in our life time?
Drug companies don’t seem very interested in funding a search for a cure or even expanding on what is now know.

Even without research, we now already know that most cases of type 2 diabetes respond immediately to a well managed diabetic diet coupled with exercise.  It is a case of  “stop eating and sitting yourself to death.”

There are several articles on this site about research into using a generic vaccine to work on curing or reversing type 1 diabetes.

Also included is an excerpt from a report by British Physicians stating that they had successfully reversed type 2 diabetes completely.  If you go and read, please comment below what you think about the information…and how it should be used.

Free Screening During World Diabetes Month

Bernews – ‎25 minutes ago‎
Bermuda Hospitals Board joins a global diabetes campaign this month highlighting the importance of education in order to protect the future health of our communities and prevent the serious health consequences of this disease. The hospital will be offering 
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Diabetes Raises Alarm, Improve Your Quality of Life

Top News Arab Emirates – ‎1 hour ago‎
American Diabetes Month is being observed in November. Diabetes is raising high alarms as 26 million people in America, including children are prone to the disease, according the American Diabetes Association. Even bigger matter of concern is that, 

Association Warns That Type 2 Diabetes Increases Risk For Cardiovascular 

NJ TODAY – ‎3 hours ago‎
ROBBINSVILLE — November is national diabetes month and the American Heart Association/American Stroke Association warns that people living with type 2 diabetes are at an increased risk for cardiovascular diseases, such as stroke or heart attack.

American Diabetes Association Makes Recommendations

Enon Eagle – ‎8 hours ago‎
Written by Kathy Voytko. Wednesday, 07 November 2012 00:00. November is American Diabetes month, and the work of the American Diabetes Association will focus on spreading the word about the prevalence, toll on health and cost of diabetes this month.

type 2 diabetes

Will Eating Only Raw Food Help Control High Blood Sugar?

type 2 diabetes

Will a diet low in fat and high in sugar work for a diabetic to control blood sugar?

How will a Diet of Raw Fruit affect blood sugar control?

Swayze Foster at http://www.fitonraw.com  wrote an article about an experiment she conducted on herself.  Since she doesn’t say  she is a diabetic, but  had access to and used a glucose meter to keep track of her sugar when she converted to eating fruit for 7 days we can assume she was interested in losing weight and what would work.

The reason being, when dieting and trying to lose weight, one of the pitfalls is when calories consumed are used up and we end up with low blood sugar with our insides calling for more food…so off the diet and over eat!

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Raw Fruit with Strawberries, Kiwi and apple slices

Below is an excerpt from the article she wrote about her 7 day Eating Raw Experiment.
Recently, I wanted to prove that a low fat, high fruit raw vegan diet does NOT lead to high blood sugar. Using a standard blood glucose monitor, I measured my blood glucose level several times a day for seven days.

The results may shock you.

Over the entire seven days, taking three readings each day, my blood glucose level never went above the normal range for fasting blood glucose OR postprandial blood glucose. Not even once.

Not even seconds after finishing off a large 800+ calorie fruit meal! So if a diet so high in sugar doesn’t lead to high blood sugar, what does?

It Isn’t the Fruit  Sugar doesn’t lead to high blood sugar, no matter how much you eat. Because it doesn’t have to be broken down and converted to glucose (everything you eat has to be converted to simple sugar before it can be absorbed and assimilated by the body), the sugar from fruit is quickly absorbed into the bloodstream.

Contrary to popular belief, this speedy absorption is actually a good thing. It means that you’ll be quickly satiated (you won’t overeat) and quickly fueled (great for physical and mental performance).

Once the sugar is in the bloodstream, insulin is sent from your pancreas to your bloodstream. The insulin then transports the sugar from the blood and into your cells. In a normal and healthy human body, the sugar from fruit is digested, absorbed, assimilated, and even eliminated quickly and easily. It’s the Fat

Will a diet High in Fat Contribute to and Raise Blood Sugar Levels?

Swayze continues on with her theory that sugar isn’t the cause of high blood sugar, but excess fat in the diet  which seemingly coats your circulatory system, the liver and the pancreas thereby preventing normal absorption of sugar….therefore high blood sugar levels result and eventually lead to the development of diabetes.

She also hypothesized that raw or cooked, excess fat is excess fat regardless if from raw nuts or avocado or other sources and should be kept very low in your calories count. Here is part of a study she presented in the original article.
               

*Low-Fat Diet Alone Reversed type 2 diabetes in Mice*

This study was conducted at Duke University Medical Center in 1999. The researchers took a group of diabetes-prone mice and reduced their diet from 40% fat to 10% fat. The results?  Total reversal of their diabetes. And this wasn’t just due to weight loss because……their insulin and glucose (blood sugar) levels began to decrease before their weight did, suggesting that fat reduction acts on insulin and glucose levels independent of weight loss. What’s even more interesting is that sugar had absolutely no effect on the mice in terms of either increasing or decreasing their symptoms.  To read more of Swayze’s article you may go here.  Article Source: http://EzineArticles.com/?expert=Swayze_Foster

The results from the above study and another cited in Swayze’s article concluded that even humans can benefit from eating a diet high in Raw Carbs…in other words eat RAW fruit and vegetables and keep fat from all sources to 10% or less of total calories.

There are several good plans available detailing Raw Vegan Diets, to continue reading more about Raw eating Click Here!

lose fat
Eating Raw for Energy and blood sugar control.

 

type 2 diabetes

Is Controversial TB Vaccine the Cure for Type 1 Diabetes?

Research updates on using Controversial TB Vaccine to Cure or Reverse Type 1 Diabetes. Links to academic publications, background and education on Dr. Denise Faustman are included.

90 year Old Tuberculosis Vaccine Being Studied as Cure for Type 1 Diabetes

Fact Sheet on Denise Faustman Research Download PDF file Here

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Dr. Faustman researches use of Controversial Tuberculosis Vaccine to Cure Type 1 Diabetes.

Articles and News Reports on Research on Type 1 Diabetes are available here.  Dating back to 2006 this list of Media Coverage details the progress and sometimes the road blocks to progress.  Links go to PDF articles, Pod casts and archived Radio broadcasts.

 

http://www.faustmanlab.org/news/news_mc.html

Below is part of an article retrieved from Wikpedia, I have left most links intact.    All this information gives some background into the ongoing research for a cure for Type 1 Diabetes and several other Immunological based diseases including Rheumatoid Arthritis.  http://faustmanlab.org/images/Faustman2.jpg

“Bacillus Calmette-Guerin vaccine”

Further information: Bacillus Calmette-Guérin

Former Chrysler chairman Lee Iacocca, whose wife died of type 1 diabetes complications and who has declared a desire to see the disease cured in his lifetime,[11] is a patron of her work. The Iacocca Foundation helped raise the $11.5 million dollars needed to support a Phase I human clinical trial at Massachusetts General Hospital to test whether vaccination with Bacillus Calmette-Guerin (BCG), a weakened strain of bacteria that is used in the prevention of tuberculosis and in the treatment of bladder tumors and bladder cancer, as a treatment for advanced type 1 diabetes. Like CFA in the mouse, BCG induces TNF-α production in humans (CFA is not approved for use in humans). In previous human trials, BCG has not generally been shown to have a benefit in the prevention of type 1 diabetes or remission of the disease in those who are newly diagnosed,[12][13][14][15][16] although one study from Israel did show a benefit (disease remission) in newly diagnosed type 1 diabetes.[17]Faustman hypothesizes that the optimal dosing of BCG has not been utilized in previous trials.[2]    http://en.wikipedia.org/wiki/Wikipedia:Text_of_Creative_Commons_Attribution-ShareAlike_3.0_Unported_License “

Keeping up todate with research is important.  Supporting research is even more important.  Just from reading some of the reports, it is possible that the best results were obtained when using an anti inflammatory plus the TB vaccine in mice who had spontaneously developed Type 1 Diabetes.  However this particular drug was not approved for humans so a different approach is being used.

If you are interested in supporting this research, you can click on this link and will be taken to a page where the program and the goals are explained.  There is a link for donations on the page.  http://faustmanlab.org/support/support_bro.html  There are two downloadable pdf files that you can share.

Here is a link to a page that lists Denise Faustman’s Academic Publications  beginning in 1982.    http://www.faustmanlab.org/research/research_ap.html  Some of it is heavy reading, but charts and graphs do make some of the information more accessible and understandable.

A lot of links and information, but hopefully useful to you, which is my intent.

Link for picture http://creativecommons.org/licenses/by-nc-sa/2.0/

 

Reverse Type 1 Diabetes? Will 90 Year old TB Vaccine Reverse Diabetes1

Does the refusal of Drug Companies to invest in a Vaccine that might cure or reverse Type 1 diabetes label them morally lacking and greedy? Researchers are trying to raise funds for research after being turned down.

Reverse Type 1 Diabetes?  The Impossible Dream?

 Will a 90 Year Old TB Vaccine do the Impossible and Reverse Type 1 Diabetes?

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I was surprised when I saw this article that I have included several excerpts from below.

As a retired R.N. it was ingrained that there is no cure or reversal for type 1 diabetes.

Sometimes with vigorous dieting and calorie control it has been documented that there is possible “reversal” of type 2 diabetes.  There are at least two articles on this site reviewing the claims of reversal.

The following information is New to me and may be to you also.  It looks like we need to get behind this movement to raise funds for research, since according to the article..it isn’t a “profitable” proposition for Drug companies to develop a “vaccine” to cure type 1 Diabetes.

Funding needed for Research

“A tuberculosis vaccine in use for 90 years may help reverse Type 1 diabetes and eliminate the life- long need for insulin injections, say Harvard University researchers raising moneyto conduct large, human studies.  

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90 year old Tuberculosis Vaccination may prove to be effective in reversing or curing type 1 diabetes.

 

“We think this can be taken all the way to the market and that is what we are trying to do.” said Denise Faustman, director of Harvard-affiliated Massachusetts General Hospital’s immunobiology laboratory, who led the study.

“These patients have been told their pancreases were dead,” Faustman said. “We can take those people, give them a very low dose twice and see their pancreases kick in and start to make small amounts of insulin.”

To Market

Faustman and her colleagues at Massachusetts General in Boston are working to get the vaccine to market. After their early findings in studies with mice, she said they tried to interest every major drugmaker in developing the vaccine as a possible cure for diabetes. All told her there wasn’t enough money to be made in a cure that used an inexpensive, generically available vaccine, Faustman said.

So now, she is trying to raise money to pay for the expensive larger human trials. Her lab so far has received $11 million of the $25 million needed to pay for the next stage of testing. All of the money is coming from private donors, the largest of which is the Iacocca Family Foundation.”  By Shannon Pettypiece – Aug 9, 2012 7:13 AM CT Shannon Pettypiece in New York atspettypiece@bloomberg.nethttp://www.bloomberg.com/news/2012-08-08/diabetes-may-be-reversed-by-long-used-vaccine-for-tb.html

To me this is a pitiful statement about the Health Care System is this country and the Drug Supply Companies that are supported by the Health Care System.

From the reported reaction by Drug Companies to requests to  invest any money in a “cure” for type 1 Diabetes, It was made abundantly clear that Profit and not concern for people is the motivation perminating  this combination of bed fellows (Health Care System and Drug Companies).

If the Health Care System, who by prescribing “drugs & treatments”  helps maintain the Drug Companies, neither of whom seem to  have the higher priority of cure rather than just treat the symptoms  then what  can force these two intertwined entities to change their focus  to Patient benefits instead of “how much can we make on this one?”

What is sad is that there is probably data available in someones  data base, where human trials were conducted on this vaccine that might even answer all the questions being posed about using it in a “new” way.   Plus not even mentioned, physicians often use “approved” drugs to treat an illness that it was not specifically tested and research for.   Sometimes the “side effect ” of a drug may be very efficient in treating an illness that it was not  researched for.

There has to be a marriage between Capitalism and Plain old Greed that reintroduces the Moral responsibility back into Capitalism.  I believe if you are earning your income from a certain area of the economy then you have a responsibility to reinvest or return some of that income back to maintain  the economy.   Make Sense?  I didn’t say all, or even a percentage, just get off the Greed train of Profit only for me and my investors and work at preserving opportunity for the future.

Do you Agree?  Disagree?   Comment below,  and Share….